| 发明名称 |
FGFR/PD-1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER |
| 摘要 |
Provided herein are combination therapies for the treatment of cancer. In particular, the disclosed methods are directed to treatment of cancer in a patient comprising administering an antibody that blocks the interaction between PD-1 and PD-L1 and an FGFR inhibitor, wherein the antibody that blocks the interaction between PD-1 and PD-L1 and the FGFR inhibitor are administered if one or more FGFR variants are present in a biological sample from the patient. |
| 申请公布号 |
US2016287699(A1) |
申请公布日期 |
2016.10.06 |
| 申请号 |
US201615079136 |
申请日期 |
2016.03.24 |
| 申请人 |
Janssen Pharmaceutica NV |
发明人 |
KARKERA Jayaprakash;Platero Suso Jesus;Verona Raluca;Lorenzi Matthew V. |
| 分类号 |
A61K39/395;G01N33/574;C12Q1/68;A61K31/498 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cancer in a patient, comprising:
administering to the patient a pharmaceutically effective amount of an antibody that blocks the interaction between PD-1 and PD-L1 and a pharmaceutically effective amount of an FGFR inhibitor, wherein the antibody that blocks the interaction between PD-1 and PD-L1 and the FGFR inhibitor are administered if one or more FGFR variants are present in a biological sample from the patient. |
| 地址 |
Beerse BE |
