| 摘要 |
FIELD: pharmaceutics.SUBSTANCE: present invention relates to novel compounds of formula I or pharmaceutically acceptable esters or phosphate, which are used for treating squamous cell carcinoma/hepatoma, to a pharmaceutical composition based thereon, to a method of treating squamous cell carcinoma/hepatoma and to a method of producing compounds of formula I. In formula I : R′, R denote hydrogen or Calkyl; R, R, Reach independently represents hydrogen, Calkyl or; and at least one from R, R, Ris; R, R, Reach independently represents hydrogen, Calkyl, (CH)-CHOH or (CHOH)-CHOH, n = 0-3; and at least one of R, R, Ris (CH)-CHOH or (CHOH)-CHOH, n = 0 to 3. Invention also relates to intermediate compounds of formula II, where R′, R denote hydrogen or Calkyl; X, X, Xindependently represents hydrogen, Calkyl or, where Rand Reach independently denotes hydrogen or Calkyl; at least one of X, X, Xis.EFFECT: treatment of squamous cell carcinoma/hepatoma.9 cl, 7 dwg, 3 tbl, 22 ex |
