| 摘要 |
The invention relates to a method of obtaining 3,3-diphenylpropylamines (I), wherein R 1 is H, alkyl, haloalkyl or alkoxyalkyl, R 2 is alkyl, alkoxy, halogen, NO 2 , CN, CHO, which may be free or protected, CH 2 OH or COOR 6 , and R 3 and R 4 are selected independently from H and alkyl or together with the nitrogen to which they are bound form a ring having 3 to 7 members. The inventive method consists in reacting a propylenephenylamine and a disubstituted aromatic hydrocarbon and, if necessary, separating the desired enantiomer or the mixture of enantiomers, and/or converting the compound (I) into a salt. Compounds (I) are muscarinic receptor antagonists which can be used in the treatment of urinary incontinence and other symptoms of urinary bladder hyperactivity. Said compounds include tolterodine. |
