发明名称 Wnt antagonists and methods of treatment and screening
摘要 Disclosed is the use of a Wnt-binding agent that comprises: (a) a first polypeptide comprising SEQ ID NO:39, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:40, or SEQ ID NO:41; and (b) a second polypeptide comprising SEQ ID NO:42; wherein the first polypeptide is directly linked to the second polypeptide, for the manufacture of a medicament for the treatment of cancer, wherein the cancer is pancreatic cancer, hepatocellular cancer, or ovarian cancer (sequences as defined in the specification).
申请公布号 NZ700085(A) 申请公布日期 2016.05.27
申请号 NZ20110700085 申请日期 2011.01.12
申请人 ONCOMED PHARMACEUTICALS INC. 发明人 MITRA SATYAJIT SUJIT KUMAR;SATYAL SANJEEV H;GURNEY AUSTIN L
分类号 A61K38/00;C07K1/00 主分类号 A61K38/00
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