| 主权项 |
1. A urotensinergic agent or a pharmaceutically acceptable salt thereof having the formula: wherein X is a L- or D-amino acid selected from the group consisting of glycine, serine, threonine, cysteine, valine, leucine, isoleucine, methionine, proline, phenylalanine, tyrosine, aspartic acid, glutamic acid, asparagine, glutamine, histidine, lysine, arginine and side-chain conformationally constrained phenylalanines, wherein the conformationally constrained phenylalanines are selected from the group consisting of β-β-diphenylalanine and 4-amino-indolo[2,3-c]azepin-3-one, or a phenylalanine analogue having the formula:wherein R is a substituent introduced by metal catalysed reaction using a boronic acid, a boronic acid derivative, a substituted vinyl, or a substituted alkynyl. |
