Method for hyperpolarization transfer in the liquid state

摘要

A method for producing a hyperpolarized sample for use in a magnetic resonance investigation has the following steps: a) providing a solid sample (50), containing long T1 nuclei and short T1 nuclei in the same molecules (51); b) hyperpolarizing the short T1 nuclei in the solid sample (50); c) transforming the solid sample (50) into a liquid sample (52); and d) transferring the polarization of the short T1 nuclei to the long T1 nuclei within the molecules in the liquid sample (52) by Cross Polarization. The method can provide samples with hyperpolarized long T1 nuclei, in particular 13C or 15N, in a simple and efficient way.

主权项

1. A method for producing a hyperpolarized sample for use in a magnetic resonance investigation, the method comprising the steps of:
a) providing a solid sample containing long Tl nuclei and short T1 nuclei in same molecules; b) hyperpolarizing the short T1 nuclei in the solid sample; c) transforming the solid sample into a liquid sample; and d) transferring a polarization of the short T1nuclei to the long T1 nuclei within the molecules in the liquid sample by Cross Polarization via J coupling.