| 主权项 |
1. A compound of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, or a solvate thereof, wherein: W is independently selected from:
W is independently selected from: X is independently selected from: CR13 and N;L is independently C1-5 alkylene substituted with 0-2 R9 or C2-5 alkenylene substituted with 0-2 R9; optionally one of the carbon atoms of said alkylene and alkenylene may be replaced by O, S, SO2, NH, N(C1-4 alkyl), N(C1-4 fluoroalkyl), and N(—CH2—C3-6 carboycle);R9 is independently selected from: halogen, C1-4 alkyl, C1-4 haloalkyl, hydroxy, C1-4 alkoxy, and C1-4 haloalkoxy; optionally when two R9 groups are substituted on the same carbon atom of L, they may combine, with the carbon atom to which they are attached, to form a C3-6 cycloalkyl ring;R1 and R2 are independently selected from: H, OH, halogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C2-4 alkenyl, C2-4 alkynyl, —(CH2)0-1—C3-6 carboycle and —O—(CH2)0-1—C3-6 carboycle;R3, R4 and R7 are independently selected from H, halogen, C1-2 alkyl, C1-2 alkoxy, and C1-2 haloalkoxy;R5 is independently selected from: H C1-2 alkyl, and C1-2 haloalkyl;R6 is independently selected from: H, CN, C1-4 alkyl, —CO2H, CO2(C1-4 alkyl), —CH2CO2H, and —CH2CO2(C1-4 alkyl);R8 is independently selected from: H, halogen, CN, OH, SH, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, C1-4 haloalkylthio, —SO2(C1-4 alkyl), —SO2(C1-4 haloalkyl), —SO2(C3-6 cycloalkyl), —SO2NH2, —SO2NH(C1-4 alkyl), —SO2N(C1-4 alkyl)2, and —SO2(C3-6 cycloalkyl);R12 is independently selected from H, halogen, CN, —C(═NH)NH2, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CH2NH2, CH2NH(C1-4 alkyl), CH2N(C1-4 alkyl)2, C(O)NH2, C(O)NH(C1-4 alkyl), and C(O)N(C1-4 alkyl)2; andR13 and R14 are independently selected from: H, F, Cl, C1-2 alkyl, and C1-2 alkoxy. |
