| 发明名称 |
COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESIS |
| 摘要 |
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt~1 and Flk-l/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs. |
| 申请公布号 |
CA2493499(C) |
申请公布日期 |
2016.04.12 |
| 申请号 |
CA20032493499 |
申请日期 |
2003.07.18 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
TOLENTINO, MICHAEL J.;REICH, SAMUEL JOTHAM |
| 分类号 |
A61K9/127;A61K31/7105;A61K38/00;A61K48/00;A61P17/06;A61P19/02;A61P35/00;C07H21/02;C12N5/071;C12N15/113;C12N15/86 |
主分类号 |
A61K9/127 |
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