| 摘要 |
Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D3 receptor, 5-HT1A receptor and 5-HT2A receptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof.; |
| 主权项 |
1. A benzoisothiazole compound, characterized in that it is a compound having the structure of general formula (I) or the geometric isomers, free alkalies, salts, hydrates or solvates thereof: wherein: W is: R1 and R2 independently represent heteroaryl or substituted heteroaryl; n is 0, 1, 2 or 3; m is 0, 1 or 2; R3 represents C3-C4 alkyl, substituted C1-C4 alkyl, C3-C6 cycloalkyl, substituted C3-C6 cycloalkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, heteroaryl, substituted heteroaryl, heteroarylmethyl, or substituted heteroarylmethyl; R4 is hydrogen atom or C1-C4 alkyl; R5 is phenyl, substituted phenyl, heteroaryl or substituted heteroaryl. |
