1-ARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES, 1-HETEROARYL-1-HYDROXY-2,3-DIAMINO-PROPYL AMINES AND RELATED COMPOUNDS HAVING ANALGESIC AND/OR IMMUNO STIMULANT ACTIVITY

摘要

Compounds of the formula;;where the variables have the meaning defined in the specification have analgesic and/or immunostimulant effect in mammals.

主权项

1. A compound of the formula:or a pharmaceutically acceptable salt thereof, wherein:
R1 and R2 together form a morpholine or a pyrrolidine; R3 is selected from the group consisting of H, CH2(CH3)Ph, and CO—R7; R4 is selected from the group consisting of H, and CO—R8; R7 is selected from the group consisting of benzyl and alkyl of 1 to 20 carbons; R8 is selected from the group consisting of alkyl of 1 to 20 carbons; and R10 is selected from the group consisting of phenyl, methoxy-substituted phenyl,where the * indicates the carbon to which the remaining moiety of the molecule is attached.