发明名称 |
NOVEL SYNTHETIC PROCESS TO 8-CHLORO-1-METHYL-BENZO[D]AZEPINE, NOVEL INTERMEDIATES AND THE PRODUCTION THEREOF |
摘要 |
The present invention is directed to a simple and economical process for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine via novel intermediates and a highly selective asymmetric synthesis leading to enantiopure (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d] azepine or its (S)-enantiomer, in order to avoid or overcome chemical optical resolution. |
申请公布号 |
EP2989082(A1) |
申请公布日期 |
2016.03.02 |
申请号 |
EP20140719726 |
申请日期 |
2014.04.23 |
申请人 |
LEK PHARMACEUTICALS D.D. |
发明人 |
STAVBER, GAJ;CLUZEAU, JEROME;RICHTER, FRANK;LAUS, GERHARD;GAZIC SMILOVIC, IVANA |
分类号 |
C07D223/16;C07C233/31;C07D291/04 |
主分类号 |
C07D223/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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