Compounds for the treatment of dyslipidemia and related diseases

摘要

The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. The present invention is directed to compounds suitable for the treatment of Disease conditions such as hyperlipidemia.;

主权项

1. Compounds of formula (I) their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them wherein ‘ZA’ represents an optionally substituted (C6)aryl group; each of ‘X’ and ‘Z’ independently represents an optionally substituted group selected from (C6)aryl, (C2-C5)heterocyclyl containing one or more heteroatoms selected from O, N, and S or (C3-C6)cycloalkyl groups; R1, R2 and R3 independently at each occurrence represents H, (C1-C6) linear or branched alkyl, (C2-C6) linear or branched alkenyl, (C2-C6) linear or branched alkynyl, hydroxy, (C1-C6) alkoxy, (C2-C6) alkenoxy, hydroxy(C1-C6)alkyl, (C1-C6)alkoxy(C1-C6)alkyl, halo(C1-C6)alkyl, (C3-C6)cycloalkyl, thio(C1-C6)alkyl, (C1-C6)alkylthio, halo, oxo, imino, nitro, (C6)aryl, amino, amino(C1-C6)alkyl, cyano, formyl, halo (C1-C6)alkoxy, (C6)aryloxy, (C6)ar(C1-C6)alkyl, (C6)ar(C1-C6)alkoxy, carboxylic acid, —COOCH3, —COOCH2CH3, —CONH2, (C1-C6)alkylsulfonyl, (C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonyloxy, each of which may be optionally substituted; ‘m″n’ and ‘o’ independently represents integers from 0 to 3; ‘Y’ represents O; ‘W’ represents (C1-C6) alkyl; ‘V’ represents O or S.