| 主权项 |
1. A compound of Formula (I) or an enantiomer, a diastereomer, or a mixture thereof, or a pharmaceutically acceptable salt or solvate thereof: wherein: E is —X3═X4—, and X1, X2, X3 and X4 are independently C(R2); (G) is an aryl or heterocyclyl group; each (R1) is independently chosen from alkyl, alkenyl, alkynyl, cyclyl, -L1-cyclyl, -L1-amino, -L1-hydroxyl, amino, amido, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, hydroxyl, alkoxy, urea, carbamate, acyl, and carboxyl; each (R2) is independently chosen from —H, alkyl, alkenyl, alkynyl, cyclyl, -L1-cyclyl, -L1-amino, -L1-hydroxyl, amino, amido, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, hydroxyl, alkoxy, urea, carbamate, acyl, and carboxyl, wherein each (R2) group has 1, 2, or 3 independently chosen optional substituents or two (R2) groups can be taken together to form a heterocyclyl or aryl group having 1, 2, or 3 independently chosen optional substituents, wherein said optional substituents are independently chosen from alkyl, alkanoyl, heteroalkyl, heterocyclyl, haloalkyl, cycloalkyl, carbocyclyl, arylalkoxy, heterocyclylalkoxy, aryl, aryloxy, heterocyclyloxy, alkoxy, haloalkoxy, oxo, acyloxy, carbonyl, carboxyl, carboxamido, cyano, halogen, hydroxyl, amino, aminoalkyl, amidoalkyl, amido, nitro, thiol, alkylthio, arylthio, sulfonamide, sulfinyl, sulfonyl, urea, and carbamate; R3 is —H or a (C1-C6)alkyl group; each L1 is independently alkylene or heteroalkylene; and n is 0, 1, 2, 3, 4 or 5;with the proviso that the compound of Formula (I) is not:
(1S,2R)-2-([1,1′-biphenyl]-4-yl)cyclopropanamine, (1S,2R)-2-(4′-chloro-[1,1′-biphenyl]-4-yl)cyclopropanamine, (1S,2R)-2-(3-chloro-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)cyclopropanamine, 2-(3,4′,5-trichloro-[1,1′-biphenyl]-4-yl)cyclopropanamine, 2-(3,3′,4′,5-tetrachloro-[1,1′-biphenyl]-4-yl)cyclopropanamine, 2-(3,3′,4′-trichloro-[1,1′-biphenyl]-4-yl)cyclopropanamine, or 2-(3,5-dichloro-4′-methyl-[1,1′-biphenyl]-4-yl)cyclopropanamine. |
