| 发明名称 |
IMMUNOTHERAPEUTIC MOLECULES AND USES |
| 摘要 |
The invention provides molecule comprising: (i) a targeting moiety capable of directly or indirectly targeting to unwanted cells, and (ii) a further moiety that has a masked immune cell binding region so as to prevent binding of the further moiety to an immune cell, wherein the masked immune cell binding region is capable of being selectively unmasked when the molecule is in the vicinity of the unwanted cells so as to allow binding of the further moiety to an immune cell. |
| 申请公布号 |
US2016039942(A1) |
申请公布日期 |
2016.02.11 |
| 申请号 |
US201514918807 |
申请日期 |
2015.10.21 |
| 申请人 |
UNIVERSITY OF BIRMINGHAM |
发明人 |
Cobbold Mark;Millar David |
| 分类号 |
C07K16/28;A61K45/06;A61K39/395 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising:
(i) a targeting moiety capable of directly or indirectly targeting to unwanted cells, and (ii) at least one further moiety that has a masked immune cell binding region so as to prevent binding of the further moiety to an immune cell, wherein the masked immune cell binding region, optionally a T cell binding region, is capable of being selectively unmasked, optionally by selective cleavage of one or more linkers that contain cleavage sites or a conformational change in the further moiety that unmasks the immune cell binding region, when the molecule is in the vicinity of the unwanted cells so as to allow binding of the further moiety to an immune cell. |
| 地址 |
Birmingham GB |
