METHODS AND APPARATUS FOR TREATMENT OF CHRONIC KIDNEY DISEASE

摘要

A method and apparatus for treatment of chronic kidney disease (CKD), particular diabetic nephropathy, are disclosed. The method comprises activation of adenosine A2a receptors in parenchymal and immune cells infiltrated into kidneys. The activation is performed by PEMF (pulsed electromagnetic field) stimulation applied locally to kidneys. Adenosine A2a signaling pathway is a potent anti-inflammatory and immuno-suppressive regulator that has been proven to attenuate inflammation and injury in diabetic nephropathy. Efficient activation of A2a receptors is achieved by applying electromagnetic field stimulation consecutively in 3 spatial dimensions. This allows attaining a significant increase in activation of A2a receptors in comparison with one-dimensional stimulation. Assistant thermal stimulation may be applied to increase expression of heat shock proteins (HSPs) in parenchymal cells. HSPs improve protein functions, protect cells from apoptosis and necrosis, increase metabolism, and symbiotically enhance effects of electric stimulation on CKD.

主权项

1. A pulsed electromagnetic field therapy stimulation system for delivering treatment to a patient with chronic kidney disease, the system comprising:
an applicator; a first stimulation unit disposed in the applicator and located such that the first stimulation unit is disposed over a first kidney of the patient when the applicator is worn by the patient, the first stimulation unit comprising:
a first coil comprising a first petal and a second petal, the second petal extending longitudinally opposite the first petal along a first longitudinal axis, and defining a first coil crossover point where the first and second petals intersect;a second coil comprising a first petal and a second petal, the second petal extending longitudinally opposite the first petal along a second longitudinal axis, and defining a second coil crossover point where the first and second petals intersect; anda third coil comprising a perimeter loop,wherein the first coil, second coil and third coil are disposed in a plane,wherein the first longitudinal axis is axially rotated ninety degrees with respect to the second longitudinal axis,wherein the first coil crossover point and second coil crossover point coincide, andwherein the first coil and the second coil are disposed within the perimeter loop of the third coil.