DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES

摘要

This invention relates to novel 2-amino-3-hydroxypropanoic acid derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an NMDA glycine-site antagonist.

主权项

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:
Y1 is selected from CH3, CH2D, CHD2 or CD3; each Z variable is independently selected from hydrogen or deuterium; and each R variable is independently selected from hydrogen or deuterium; wherein any atom not designated as deuterium is present at its natural isotopic abundance; and wherein for each site designated as deuterium, deuterium incorporation is at least 90%.