COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN

摘要

Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

主权项

1. A compound of formula (I): or an N oxide thereof, or a pharmaceutically acceptable salt of each thereof, wherein A is selected from the group consisting of: wherein R1 is C1-C6 alkyl optionally substituted with 3-6 fluoro atoms; R2 is hydrogen or C1-C6 alkyl; R3 is C1-C6 alkyl; each R4 independently is hydrogen or C1-C6 alkyl; ring B is or ring B together with A is: X is oxygen. S, SO, or SO2; ring C is selected from the group consisting of; wherein R5 is selected from the group consisting of hydrogen; C1-C6 alkoxy, optionally substituted with a C1-C6 alkoxy group or with up to 3 fluoro atoms; C1-C6 alkyl; and halo; R6 is hydrogen or halo; R is hydrogen, a phosphate, a diphosphate, a phosphonate or a phosphoramidate containing moiety, or another promoiety; provided that the compound of formula (I) comprises at least 1 OR group where R is not hydrogen.