| 摘要 |
The present invention relates to a pharmaceutical composition for oral administration, which comprises oseltamivir free base, preferably, oseltamivir free base whose 90% of particles have sizes less than or equal to 200 μm. Also, the present invention relates to a medication including the composition and a manufacturing method of the same. The pharmaceutical composition of the present invention can be forms of capsules, tablets, dry syrups, chewable tablets, or powder. Rather than oseltamivir phosphate, oseltamivir free base is confirmed to have distinctively higher solubility. If the size of the free base is reduced to be in a particular range, initial release rate at a desired level can be achieved. Particularly, if the size of the oseltamivir free base is limited to be in the said range, change in solubility is minimized and deviation in the release rates can also be minimized. Therefore, quality control at a manufacturing site can be usefully performed. |
