发明名称 |
T-CELL RECEPTOR CAPABLE OF RECOGNISING AN ANTIGEN FROM CYTOMEGALOVIRUS |
摘要 |
<p>The present invention provides a T-cell receptor (TCR) which binds to a peptide from the cytomegalovirus (CMV) phosphoprotein pp65 having the amino acid sequence NLVPMVATV (SEQ ID No. 1) when presented by a major histocompatability complex (MHC) molecule. The present invention also provides a nucleotide sequence encoding such a TCR, a vector comprising such a nucleotide sequence and its use to produce a CMV-specific T-cell. The present invention also provides the use of CMV-specific T-cell for cellular immunotherapy.</p> |
申请公布号 |
EP2483303(B1) |
申请公布日期 |
2016.01.06 |
申请号 |
EP20100777060 |
申请日期 |
2010.09.29 |
申请人 |
UCL BUSINESS PLC |
发明人 |
STAUSS, HANS;XUE, SHAO-AN |
分类号 |
C07K14/725;A61K38/17;C12N15/12 |
主分类号 |
C07K14/725 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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