PEPTOIDS THAT BIND SPECIFIC ANTIGENS

摘要

Combinatorial libraries were generated providing a vast number of diverse peptoid ligands. From these libraries, ligands were identified which specifically bind molecules associated with autoimmune diseases, such as antibodies specific to aquaporin-4 (AQP4), binding of which to AQP4 causes the autoimmune disease, Neuoromyelitis Optica. Methods of generating peptoid libraries and for diagnosing Neuromyelitis Optica are also provided.

主权项

1. A method of identifying ligands which specifically bind to receptors associated with autoimmune diseases, the method comprising:
providing a compound library of candidate ligands wherein each ligand is coupled to a support; contacting the library with a control sample and removing ligands associated with non-specific binding and/or specific ligands against antibodies common in healthy people; contacting the remaining ligands with a test sample and a labeled secondary antibody; and, identifying ligands which specifically bind to receptors associated with autoimmune diseases.