| 发明名称 | Gigaxonin fusion protein and methods for treating giant axonal neuropathy | ||
| 摘要 | The present disclosure relates generally to fusion proteins including gigaxonin coupled to a cell penetrant peptide. These fusion proteins can be used to treat GAN in a subject in need thereof. Administration of the fusion proteins allows for control of at least one of Galectin-1 (GAL-1) levels and phosphorylated vimentin protein levels, thereby mediating aggregation of vimentin and the formation of vimentin-free zones in cells. | ||
| 申请公布号 | US9221890(B2) | 申请公布日期 | 2015.12.29 |
| 申请号 | US201214354150 | 申请日期 | 2012.10.25 |
| 申请人 | Indiana University Research and Technology Corporation | 发明人 | Payne R. Mark;Babbey Clifford M.;Martin Kyle B.;Beard Samuel M. |
| 分类号 | A61K39/00;A61K39/385;C07K14/47;A61K38/00 | 主分类号 | A61K39/00 |
| 代理机构 | Stinson Leonard Street LLP | 代理人 | Stinson Leonard Street LLP |
| 主权项 | 1. A fusion protein comprising gigaxonin coupled to at least one cell penetrant peptide selected from the group consisting of SEQ ID NO: 1; SEQ ID NO: 2; SEQ ID NO: 3; SEQ ID NO: 4; SEQ ID NO: 5; SEQ ID NO: 6; SEQ ID NO: 7; SEQ ID NO: 8; an arginine oligomer; a 41 kDa Cre recombinase peptide; and combinations thereof. | ||
| 地址 | Indianapolis IN US | ||