UNNATURAL REACTIVE AMINO ACID GENETIC CODE ADDITIONS

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells.SOLUTION: The present invention relates to a composition containing a protein, wherein the protein comprises at least one unnatural amino acid and at least one post-translational modification, wherein the at least one post-translational modification comprises attachment of a molecule comprising a second reactive group by a [3+2] cycloaddition to the at least one unnatural amino acid comprising a first reactive group.