发明名称 |
AQUEOUS BASED PHARMACEUTICAL FORMULATIONS OF WATER-SOLUBLE PRODRUGS OF PROPOFOL |
摘要 |
<p>The present invention is directed to aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol in the absence of an antioxidant. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. The formulations can be prepared without the use of harmful co-solvents or surfactants and are stable at room temperature over extended periods of time.</p> |
申请公布号 |
EP2068630(A2) |
申请公布日期 |
2009.06.17 |
申请号 |
EP20070838542 |
申请日期 |
2007.09.20 |
申请人 |
EISAI CORPORATION OF NORTH AMERICA |
发明人 |
PATEL, KANAIYALAL, R.;DORDUNOO, STEPHEN;KELLER, DAVID |
分类号 |
A01N43/00;A61K9/00;A61K31/33;A61K31/661;A61P23/00;A61P25/20 |
主分类号 |
A01N43/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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