ENGINEERED AVIRULENT BACTERIA STRAINS AND USE IN MEDICAL TREATMENTS

摘要

Provided in part herein are avirulent bacterial compositions suitable for use as medicaments for the treatment of various tumors. Also provided in part are methods for identifying and/or generating avirulent bacterial strains or engineered avirulent bacterial strains that can be formulated as medicaments. Also provided in part are methods of cancer treatment utilizing engineered avirulent bacteria as described herein. Engineered strains as described herein show normal or increased fitness in tumor tissue, while exhibiting reduced fitness in normal tissue. Compositions described herein may prove useful for the treatment of other medical conditions.