发明名称 |
T CELL RECEPTOR AND NUCLEIC ACID ENCODING THE RECEPTOR |
摘要 |
Disclosed are: polypeptides for TCRα-chain andβ-chain which are restricted to HLA-A*0201 for Aur-A and are derived from a CTL; and nucleic acids encoding the polypeptides. The nucleic acids can impart a cytotoxic activity against a cell capable of presenting an HLA-A*0201 molecule and an Aur-A207-215 peptide thereon to a T cell, and are therefore useful for the treatment of cancer in which Aur-A is expressed.
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申请公布号 |
US2012009162(A1) |
申请公布日期 |
2012.01.12 |
申请号 |
US201013257389 |
申请日期 |
2010.04.02 |
申请人 |
YASUKAWA MASAKI;FUJIWARA HIROSHI;OCHI TOSHIKI;MINENO JUNICHI;KATO IKUNOSHIN |
发明人 |
YASUKAWA MASAKI;FUJIWARA HIROSHI;OCHI TOSHIKI;MINENO JUNICHI;KATO IKUNOSHIN |
分类号 |
A61K35/12;A61K31/7088;A61P35/00;C07H21/04;C07K14/435;C12N5/10;C12N15/63 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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地址 |
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