| 发明名称 |
INHIBITORS OF BETA-SECRETASE |
| 摘要 |
<p>The present invention relates to spirocyclic indane imidazole 4-amines and their use as inhibitors of theβ-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production ofβ-amyloid aggregates.</p> |
| 申请公布号 |
WO2014052398(A8) |
申请公布日期 |
2015.01.29 |
| 申请号 |
WO2013US61592 |
申请日期 |
2013.09.25 |
| 申请人 |
VITAE PHARMACEUTICALS, INC. |
发明人 |
VENKATRAMAN, SHANKAR;YUAN, JING;ZHENG, YAJUN |
| 分类号 |
C07D401/04;A61K31/4184;A61K31/4439;A61P25/28;C07D235/02 |
主分类号 |
C07D401/04 |
| 代理机构 |
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