| 摘要 |
PROBLEM TO BE SOLVED: To provide polymyxin derivatives and methods for treating a subject for gram negative bacterial infection by administering a combination of the polymyxin derivative and a second antibacterial agent.SOLUTION: The polymyxin derivative of the invention has a polymyxin ring moiety and a side chain of two amino acid residues, where the polymyxin ring is selected from the ring moieties of polymyxin A, polymyxin B, IL-polymyxin B1, polymyxin D, polymyxin E, polymyxin F, polymyxin M, polymyxin S, polymyxin T, circulin A, octapeptin A, octapeptin B, octapeptin C and octapeptin D. |
