ANALYSIS OF DIRECT FACTOR Xa INHIBITORS

摘要

The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.

主权项

1. Method for detecting at least one direct factor Xa inhibitor in a sample, comprising the steps of:
(a) providing a sample containing at least one direct factor Xa inhibitor; (b) providing a composition containing factor Xa; (c) providing a composition containing a chromogenic substrate conjugated to a detectable substance; (d) mixing the sample of step (a) with the composition of step (b) and the composition of step (c) under conditions which allow the binding of the at least one direct factor Xa inhibitor to factor Xa and which allow the factor Xa to release the detectable substance from the chromogenic substrate; (e) measuring the amount of released detectable substance; wherein the sample does not contain citrated blood plasma.