发明名称 |
RAPAMYCIN ANALOGS TARGETING PROTEASOME FUNCTION IN THE TREATMENT OF CANCER |
摘要 |
The invention provides for treatment of cancers using a rapamycin analog, optionally including bortezomib. In particular, the invention addresses the treatment of bortezomib-resistant cancers using seco-rapamycin and optionally a second proteasome inhibitor. This invention relates to oncology and medicine, and more particularly to treatment of cancer. In particular, rapamycin analogs such as seco-rapamycin may be used advantageously to target the proteasome in cancer cells, optionally in conjunction with proteasome inhibitors such as bortezomib. |
申请公布号 |
EP2941301(A1) |
申请公布日期 |
2015.11.11 |
申请号 |
EP20130869967 |
申请日期 |
2013.12.24 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GACZYNSKA, MARIA, E.;OSMULSKI, PAWEL, A. |
分类号 |
A61P35/00;A61K31/436;A61K31/453;A61K31/69;A61K45/06 |
主分类号 |
A61P35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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