CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE 3/4 HYDRATE, METHOD FOR PRODUCING THE SAME AND CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE HYDRATE

摘要

Provided is a method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, including:
reacting 2-aminomalonamide with a compound represented by the following formula [1] in the presence of a carboxylic acid to obtain 5-hydroxy-1H-imidazole-4-carboxamide:;wherein, in formula [1], each R independently represents a C1-3 alkyl group;reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide with an acidic compound to obtain a 5-hydroxy-1H-imidazole-4-carboxamide acid salt or a hydrate thereof; andreacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide acid salt or hydrate thereof with a salt in the presence of an acidic solvent to obtain the 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate.

主权项

1. A crystal of 5-hydroxy-1H-imidazole-4-carboxamide hydrate, wherein the crystal has diffraction peaks at diffraction angles of 8.1, 12.6, 17.1, 19.3, 20.3 and 21.6°, represented by 20 in a powder X-ray diffraction pattern.