| 主权项 |
1. A process for the preparation of compounds of formula (I) wherein Ring A and Ring B are one of the following: (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; or (2) Ring A is an optionally substituted benzene ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, or an optionally substituted unsaturated fused heterobicyclic ring wherein Y is linked to the heterocyclic ring of the fused heterobicyclic ring; or (3) Ring A is an optionally substituted unsaturated fused heterobicyclic ring, wherein the sugar moiety X-(sugar) and the moiety —Y-(Ring B) are both on the same heterocyclic ring of the fused heterobicyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an optionally substituted unsaturated fused heterobicyclic ring, or an optionally substituted benzene ring; X is a carbon atom; Y is —(CH2)n—; wherein n is 1 or 2; provided that in Ring A, X is part of an unsaturated bond; or a pharmaceutically acceptable salt or solvate thereof; comprising reacting a compound of formula (VII), wherein M2 is a zinc species, with a compound of formula (VIII), wherein each Z is pivaloyl and wherein LG2 is bromo; in a mixture of an ether solvent and a hydrocarbon solvent; wherein the ether solvent is selected from the group consisting of di-n-butyl ether and cyclopentylmethyl ether; at a temperature in the range of from about 60° C. to about 95° C.; to yield the corresponding compound of formula (IX); de-protecting the compound of formula (IX); to yield the corresponding compound of formula (I). |
