Microfluidic chip for susceptibility of superparamagnetic nanoparticles of bead and droplet types and measuring method for susceptibility using the same

摘要

The present invention relates to a microfluidic chip for measuring the magnetic susceptibility of a superparamagnetic nanoparticle droplet and a method for measuring magnetic susceptibility using the same. According to the invention, the magnetic susceptibility of a superparamagnetic nanoparticle can be continuously and accurately measured in a flowing fluid using a microfluidic chip including microfluidic channels.

主权项

1. A method for measuring the magnetic susceptibility of a superparamagnetic nanoparticle bead comprises the steps of:
(1) injecting a continuous phase fluid and a magnetic fluid into a continuous phase fluid-moving microfluidic channel and a magnetic fluid-moving microfluidic channel, respectively, in a microfluidic chip; (2) allowing the continuous phase fluid and the magnetic fluid, injected in step (1), to meet each other to form a superparamagnetic nanoparticle bead droplet; and (3) measuring the magnetic susceptibility of a superparamagnetic nanoparticle bead present in the droplet when the superparamagnetic nanoparticle bead droplet formed in step (2) passes over an active junction area of a planar Hall resistive sensor, wherein the microfluidic chip comprises a planar Hall resistive sensor comprising an active junction area for sensing the superparamagnetic nanoparticle bead and droplet, which protrudes from an underlying substrate and in which a first arm having current electrodes at both ends and a second arm having voltage electrodes at both ends cross each other, wherein the first arm has a controlled length; and microfluidic channels crossing over the active junction area of the planar Hall resistive sensor.