发明名称 |
CaSR agonists |
摘要 |
By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof. |
申请公布号 |
US9174932(B2) |
申请公布日期 |
2015.11.03 |
申请号 |
US201414229152 |
申请日期 |
2014.03.28 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
Sugiki Masayuki;Okamatsu Toru;Asari Sayaka;Kawato Yayoi;Hatanaka Toshihiro;Yano Tetsuo;Seki Yukie;Miyamura Naohiro;Nagasaki Hiroaki;Eto Yuzuru;Yasuda Reiko |
分类号 |
C07C237/04;C07C309/51;C07F9/38;A23L1/228;A23L1/305;C07F9/40;A23L1/226 |
主分类号 |
C07C237/04 |
代理机构 |
Oblon, McClelland, Maier & Neustadt, L.L.P. |
代理人 |
Oblon, McClelland, Maier & Neustadt, L.L.P. |
主权项 |
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R3, and R5 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, —NH2, an optionally substituted alkyl group having 1 to 6 carbon atoms, and an optionally substituted alkoxy group having 1 to 6 carbon atoms; R4 is selected from the group consisting of a halogen atom, a hydroxyl group, —NH2, and an optionally substituted alkoxy group having 1 to 6 carbon atoms; R2 is selected from the group consisting of a sulfonic acid group, R6 and R7 are each independently a hydrogen atom or an optionally substituted alkyl group having 1 to 6 carbon atoms; and X is a methylene group or an oxygen atom; and excluding a compound wherein X is a methylene group, and R2 is |
地址 |
Tokyo JP |