HUMAN ANTIBODIES BINDING HUMAN TUMOR NECROSIS FACTOR ALPHA (TNF ALPHA)

摘要

The human antibodies described are preferably recombinant human antibodies which bind specifically to human tumor necrosis factor (TNF alpha). These antibodies possess high affinity to hTNF alpha (e.g. Kd = 10-8 M or less), low rate of dissociation of hTNF alpha (e.g. Koff = 10-3 sес-1 М or less) and neutralize the hTNF alpha activity in vitro and in vivo. An antibody, according to the invention, can be an antibody in its full length or its antigen-binding portion. The antibodies or a portion of the antibodies of the invention are applicable for detecting hTNF alpha and for inhibiting hTNF alpha activity. The invention also encompasses nucleic acids, vectors, and host cells for expression of recombinant human antibodies, according to the invention.