SOLID FORM ANTIVIRAL AGENT AND PREPARATION METHOD THEREFOR

摘要

The present invention relates to a novel crystal form of Tenofovir disoproxil free base. The amount of related substances generated according to an elapsed time can be minimized in the Tenofovir disoproxil free base, according to the present invention, compared with Tenofovir disoproxil fumarate or a conventional Tenofovir disoproxil free base, and thus the stability of a preparation can be increased by lowering the amount of generated impurities in a product storage process. In addition, the novel crystal form of Tenofovir disoproxil free base of the present invention has improved hygroscopicity, excellent solubility according to pH, and excellent physical and chemical properties, and thus can be used as a useful active ingredient of a pharmaceutical composition.