The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.
申请公布号
SG11201507045T(A)
申请公布日期
2015.10.29
申请号
SGT11201507045
申请日期
2014.03.07
申请人
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODYCORPORATE