Transfer device for transferring a substance between the device and a subject

摘要

A micro-needle delivery device (1) comprises an active substance accommodating layer (17) having active substance accommodating chambers (20) therein, a drive substance accommodating layer (32) having drive substance accommodating chambers (35) therein aligned with the active substance accommodating chambers (20), an activating layer (45) having heating elements (48) aligned with the drive substance accommodating chambers (35) for heating a drive substance therein, and a micro-needle element (8) having a needle support layer (9) and a plurality of micro-needles (12) extending therefrom. A burstable first membrane (22) is located between and sealably secured to the micro-needle element (8) and to the active substance accommodating layer (17) for sealably closing the active substance accommodating chambers (20) at one end. A second stretchable membrane (30) is located between and sealably secured to the drive substance accommodating layer (32) and to the active substance accommodating layer (17) sealably closes the active substance accommodating chambers (20) at the other end, and the drive substance accommodating chambers (35). A third membrane (40) sealably closes the drive substance accommodating chambers (35).

主权项

1. A micro-needle device for transferring a substance between the device and a subject, the device comprising:
a first layer having a pair of opposite major surfaces and at least one storage chamber extending into the first layer from at least one of the major surfaces thereof, a second layer comprising at least one micro-needle extending therefrom, having a first major surface, at least one communicating opening extending through the second layer from the first major surface thereof communicating with the at least one micro-needle, a membrane located between the first major surface of the second layer and the major surface of the first layer from which the at least one storage chamber therein extends, and a seal effecting projecting element extending from one of the first major surface of the second layer and the major surface of the first layer, from which the at least one storage chamber extends into the first layer, the seal effecting projecting element being of annular configuration, extending around a corresponding one of the at least one storage chamber and the at least one communicating opening and engaging the membrane and effecting a seal between the membrane and the first major surface of the second layer and the major surface of the first layer, from which the at least one storage chamber extends into the first layer, adjacent the corresponding one of the at least one storage chamber and the at least one communicating opening.