Biological Sensor and a Method of the Production of Biological Sensor

摘要

The invention is related to the field of biotechnology, specifically to the investigation of biomolecular interactions and sensing of biomolecules using a surface plasmon resonance. The biological sensor and a method of its production based on the thin films of graphene, graphene oxide, or single-walled or multi-walled carbon nanotubes are described.;The technical results of the invention are a high sensitivity of the biosensor in combination with a high biospecificity; an expansion of the range of device applications; the protection of the metal film from an environmental exposure; the possibility to detect large biological objects.;The proposed device and method of its production can be used for monitoring and recording of the concentration of chemical and biochemical substances and for the definition of parameters of biomolecular reactions in different industrial processes using biological materials, the invention can be also used in the pharmaceutical industry for the investigation of pharmacological properties and for the determination of a chemical composition of developing drugs, and also it can be used in processes of quality control of food products.

主权项

1. A biological sensor comprising:
a substrate, wherein a metal film is deposited on a surface of the substrate, wherein an intermediate binding layer with a biospecific layer adsorbed on its surface is located on an outer surface of the metal film, wherein the intermediate binding layer is composed of a thin film of graphene with a thickness of 0.3-2000 nm, or a thin film of single-walled or multi-walled carbon nanotubes with a thickness of 0.4-2000 nm, or a thin film of graphene oxide with a thickness of 0.7-2000 nm and wherein the biospecific layer is located conformally and homogeneously on the surface of the intermediate binding layer and is adapted for a specific chemical interaction with biological molecules to be analyzed.