发明名称 |
CH2 domain template molecules derived from rational grafting of donor loops onto CH2 scaffolds |
摘要 |
Novel CH2 domain template molecules wherein donor loops from a database of domains are transferred to a CH2 domain scaffold. At least one or up to three loops from a donor are transferred to the CH2 domain. The donor loops may be chosen based on length, e.g., the donor loop may have a length that is similar to that of a structural loop in the CH2 domain scaffold. |
申请公布号 |
US9156917(B2) |
申请公布日期 |
2015.10.13 |
申请号 |
US201213370831 |
申请日期 |
2012.02.10 |
申请人 |
RESEARCH CORPORATION TECHNOLOGIES, INC. |
发明人 |
Bramhill David;Raghunathan Gopalan |
分类号 |
C07K16/46;C07K16/00;C07K16/42;C40B30/04;G01N33/68 |
主分类号 |
C07K16/46 |
代理机构 |
Scully, Scott, Murphy & Presser, P.C. |
代理人 |
Scully, Scott, Murphy & Presser, P.C. |
主权项 |
1. A CH2 domain template molecule, comprising the amino acid sequence of SEQ ID NO: 97. |
地址 |
Tucson AZ US |