| 摘要 |
The present invention provides a method of producing diterpene compounds, said method comprising contacting a particular polypeptide having a diterpene synthase activity with the diterpene precursor geranylgeranyl pyrophosphate (GGPP). In particular, said method may be carried out in vitro or in vivo to produce labdenediol diphosphate, labdenediol and/or sclareol, which are very useful compounds in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing said nucleic acid, as well as a non-human organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention. |
