NANOASSEMBLED COMPLEXES OF NUCLEIC ACIDS, AVIDIN AND BIOTINYLATED COMPOUNDS FOR USE AS CARRIERS FOR INTRACELLULAR DELIVERY

摘要

It is herein described nanoassemblies of nucleic acids, avidin and biotinylated compounds for use as carriers for intracellular delivery. These nanoassemblies are composed of central nuclei of polyavidins, i.e. nuclei formed by a self- assembly of a plurality of tetrameric units of avidin on nucleic acids, on which biotinylated compounds further self-assemble by means of the high-affinity interactions between the avidin of the central nucleus and the biotin of the biotinylated compounds.