| 发明名称 |
COMPOSITION FOR INTERLEUKINE-4 CYTOKINE GENE SILENCING |
| 摘要 |
FIELD: medicine.SUBSTANCE: invention concerns a composition for the interleukin-4 cytokine gene silencing by means of an RNA interference mechanism, consisting of a cationic LTP peptide dendrimer described by formula (Arg)8(Lys)4(Lys)2Lys-Ala-Cys-NH2 used as a carrier, and two siRNA molecules described by formulas 5-UUGAUGAUCUCCUGUAAGGtt-3 and 5-AAAGAUGUCUGUUACGGUCtt-3.EFFECT: creating the low-toxic composition used for interleukin-4 gene silencing.3 cl, 18 dwg, 14 tbl, 4 ex |
| 申请公布号 |
RU2563989(C1) |
申请公布日期 |
2015.09.27 |
| 申请号 |
RU20140146661 |
申请日期 |
2014.11.20 |
| 申请人 |
FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "GOSUDARSTVENNYJ NAUCHNYJ TSENTR "INSTITUT IMMUNOLOGII" FEDERAL'NOGO MEDIKO-BIOLOGICHESKOGO AGENTSTVA ROSSII (FGBU "GNTS INSTITUT IMMUNOLOGII" FMBA ROSSII) |
发明人 |
KHAITOV MUSA RAKHIMOVICH;SMIRNOV VALERIJ VALER'EVICH;ANDREEV SERGEJ MIKHAJLOVICH;SERGEEV IL'JA VIKTOROVICH;MAERLE ARTEM VLADIMIROVICH;LOBANOVA SOF'JA BORISOVNA;KALININA ELENA VLADIMIROVNA;SHILOVSKIJ IGOR' PETROVICH |
| 分类号 |
A61K31/7088;A61K47/42;A61P37/08 |
主分类号 |
A61K31/7088 |
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