PENTACYCLIC TRITERPENE COMPOUND AND USE THEREOF IN PREPARATION OF DRUG FOR TREATING ALZHEIMER'S DISEASE

摘要

Disclosed are a pentacyclic triterpene compound represented by general formula (I) and pharmaceutical compositions containing the compound. Also disclosed is use of the compound in preparation of a PS1/BACE1 interaction inhibitor, and uses thereof in preparation of drugs for treating Alzheimer's disease. Disclosed for the first time is that a pentacyclic triterpene compound represented by general formula (I) can be used as a PS1/BACE1 inhibitor, having activity of inhibiting PS1/BACE1 interaction, and can reduce generation of Aβ and be used in preparation of drugs for treating Alzheimer's disease.