| 发明名称 |
HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN CYTOMEGALOVIRUS (CMV) GB PROTEIN |
| 摘要 |
Recombinant monoclonal antibodies to human cytomegalovirus (CMV) gB protein are described. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy. |
| 申请公布号 |
US2015252099(A1) |
申请公布日期 |
2015.09.10 |
| 申请号 |
US201514697459 |
申请日期 |
2015.04.27 |
| 申请人 |
TRELLIS BIOSCIENCE, LLC |
发明人 |
KAUVAR Lawrence M.;ELLSWORTH Stote;USINGER William;MCCUTCHEON Krista Maureen;JIANG Ying-Ping;ZHANG Fen;CHEN Bo;SPERINDE Gizette;PARK Minha;FOORD Orit |
| 分类号 |
C07K16/08;A61K39/245;C07K16/46 |
主分类号 |
C07K16/08 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Recombinant host cells comprising an expression system or expression systems for a monoclonal antibody (mAb) or antigen binding fragment thereof wherein:
(a) the heavy chain comprises the CDR1, CDR2 and CDR3 regions of the variable region of MAB4A2 (SEQ ID NO:2); or (b) comprises the CDR1, CDR2 and CDR3 regions of the heavy chain variable region of MAB19B10 (SEQ ID NO:6); or (c) comprises the CDR1, CDR2 and CDR3 regions of the heavy chain variable region of MAB313 (SEQ ID NO:13); or (d) comprises the CDR1, CDR2 and CDR3 regions of the heavy chain variable region of MAB338 (SEQ ID NO:20); or (e) comprises the CDR1, CDR2 and CDR3 regions of the heavy chain variable region of MAB345 (SEQ ID NO:22). |
| 地址 |
MENLO PARK CA US |
