BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF

摘要

Bolaamphiphilic compounds are provided according to formula I:;HG2-L1-HG1  I;where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.

主权项

1. A pharmaceutical composition comprising a bolaamphiphile complex; wherein the bolaamphiphile complex comprises one or more bolaamphiphilic compounds and a compound, metal, or an alloy capable of forming magnetic nanoparticles, wherein the bolaamphiphilic compound is a compound according to formula I:
HG2-L1-HG1  I or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, stereoisomer, tautomer, isotopic variant, or N-oxide thereof, or a combination thereof; and wherein:
each HG1 and HG2 is independently a hydrophilic head group; andL1 is alkylene, alkenyl, heteroalkylene, or heteroalkenyl linker; unsubstituted or substituted with C1-C20 alkyl, hydroxyl, or oxo.