METHOD FOR SYNTHESIZING VILDAGLIPTIN

摘要

The present invention is a method for synthesizing vildagliptin. The method comprises: performing a condensation reaction of raw materials (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile or (S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile and 3-hydroxyl-amantadine in a mixed system of an organic solvent and water under the effect of a catalyst; and after the reaction, performing extraction separation, concentration and crystallization to obtain a product with a high content, high purity and high yield. The method is concise in process, simple to operate, green and environmentally-friendly, and suitable for industrial mass production.