发明名称 |
Novel vaccines against multiple subtypes of dengue virus |
摘要 |
<p>An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.</p> |
申请公布号 |
AU2014228497(A1) |
申请公布日期 |
2015.08.20 |
申请号 |
AU20140228497 |
申请日期 |
2014.03.14 |
申请人 |
INOVIO PHARMACEUTICALS, INC.;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
WEINER, DAVID;YAN, JIAN;SARDESAI, NIRANJAN |
分类号 |
A61K31/711 |
主分类号 |
A61K31/711 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|