| 摘要 |
A compound having the structure: useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.; |
| 主权项 |
1. A compound having the formula I: or a pharmaceutically acceptable salt thereof, wherein X is O or NR7; R1 is hydrogen, —C(O)OC1-6alkyl, or —C(O)OH, or together with R2, forms ═O; R2 is hydrogen, or together with R1, forms ═O; R3 and R4 are independently
—C1-6alkyl,—CD2C1-5alkyl,—C2-5alkylene-OH,—C2-5alkylene-O—C(O)C1-6alkyl,—C1-6alkylene-aryl, or—CH2CH═CH2,or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or —C1-6alkyl; R5 and R6, which are attached to any available carbon ring atom, are independently hydrogen,
—C1-6alkyl,—C(O)OC1-6alkyl,—C(O)OH,aryl,or R5 and R6, when they are attached to the same carbon atom, together form ═O; R7 is
hydrogen,deuterium,—C1-6alkyl,—C1-6alkylene-aryl,—C1-6alkyleneC(O)O—C1-6alkyl,—C1-6alkyleneCF3,—CN,—C(O)O—C1-6alkyl,—C(O)C1-6alkyl,—C(O)OC3-6carbocycle,—C(O)CHF2,—C(O)CHF3,—C(O)CH2OH,—C(O)aryl,—C(O)C1-6alkyleneOHC(O)C3-6carbocycle,—C(O)NH2,—C(O)NHC1-6alkyl,—C(O)heterocycle,—C(O)NHC3-6carbocycle,—C(O)N(C1-6alkyl)C1-6alkyl,—C(O)NHSO2aryl,—SOC1-6alkyl,—SO2C1-6alkyl,—SO2CF3,—SO2aryl,—SO2heteroaryl,aryl,heteroaryl,heterocycle, or—C3-6carbocycle;wherein aryl, alkyl, carbocycle, heteroaryl, and heterocycle are unsubstituted or substituted with 1, 2, 3 or 4 groups independently selected from —CN, halogen, —CF3, ═O, —C(O)OC1-6alkyl or —O—C1-6alkyl. |
