Process for the production of 4-substituted chromanes via gold catalysis

摘要

Disclosed herein is single step process for the synthesis of 4-aryl substituted chromanes of compound of formula 2 comprising subjecting 3-aryloxy-1-phenylpropan-1-ol of formula 1 to (III) chloride-catalyzed intramolecular Friedel-Crafts reaction to obtain 4-aryl substituted chromanes. The invention further discloses novel 4-substituted Chromane compounds.;

主权项

1. A single step process for the synthesis of 4-aryl substituted chromanes of Formula 2 comprising subjecting 3-aryloxy-1-phenylpropan-1-ol of Formula 1 to gold (III) chloride-catalyzed intramolecular Friedel-Crafts reaction to obtain 4-aryl substituted chromanes of Formula 2 wherein ‘Ar’ is selected from the group consisting of α-Naphthyl, 4-Methylphenyl, Phenyl, β-Naphthyl, 4-Chlorophenyl, 4-Bromophenyl, 4-Fluorophenyl, 4-Cyanophenyl, 2-Methylphenyl, 2-Chlorophenyl and 2-Bromophenyl.