发明名称 |
B-CELL REDUCTION USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES |
摘要 |
The present disclosure generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the disclosure provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the disclosure provides humanized CD37-specific binding molecules. |
申请公布号 |
HRP20150591(T1) |
申请公布日期 |
2015.07.31 |
申请号 |
HR2015P000591T |
申请日期 |
2015.06.02 |
申请人 |
EMERGENT PRODUCT DEVELOPMENT SEATTLE, LLC |
发明人 |
GROSMAIRE, LAURA SUE;HAYDEN-LEDBETTER, MARTHA SUSAN;LEDBETTER, JEFFREY A.;THOMPSON, PETER ARMSTRONG;SIMON, SANDY ALEXANDER;BRADY, WILLIAM |
分类号 |
C07K16/28;A61K39/395;A61P21/04;A61P35/00;A61P37/00;C07K16/46;C12N5/10;C12N15/13;C12N15/85 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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